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Central Files is composed chiefly of correspondence sent and received between Columbia University administrators and other University officers, faculty, and trustees, as well as correspondence sent and received between University administrators and individuals and organizations from outside the university.

The collection contains correspondence, ephemera, and meeting minutes. The collection is not a comprehensive record of the College of Pharmaceutical Sciences.

The surviving files of official correspondence, reports, documents, and printed materials of King's College from 1750 to 1784 and Columbia College from 1785 to 1890, as well as Columbia University up to 1964. The King's College era materials include grants, deeds, indentures, lists of governors, leases, accounts, etc. The Columbia College era papers commence with documentation regarding the attempts to revive the college at the end of the American Revolution. In the later period these papers primarily supplement and document the minutes of the meetings of the Board of Governors and the Board of Trustees. Much material was destroyed and scattered in the late 19th century leaving this collection quite incomplete.

This collection is composed of the general files of Columbia College's Dean's Office, the minutes of Columbia College committees and the correspondence of Columbia College administrative officers during the years 1892 through 2019. A review of this collection allows researchers to gain insights into the interaction of Columbia College faculty and administrators with students, fellow faculty members, parents of students, and administrators of other colleges.

This collection contains the records of the University Committee on Student Organizations of Columbia University from its early days in 1905 through 1919.

Correspondence, memoranda, reports, notes, committee minutes, student information cards, pamphlets, flyers, and announcements relating to the Office of the Dean and the Graduate School of Arts and Sciences.