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The collection consiste of correspondence, memoranda, reports, bulletins, clippings, photographs, awards, and printed material. The files, arranged by genre and topic and reflect her philanthropic and legislative work in the areas of health, specifically cancer, heart disease, and mental health. Her civic and legislative work is covered in detail, as well as her private interests and activities.

The collection consists of the editorial and production archives of Random House, Inc. from its founding in 1925 to the 1990s. The correspondence and editorial files include many of the prominent novelists and short story writers from 20th-century American and European literature: Saul Bellow; Erskine Caldwell; Truman Capote; William Faulkner; Sinclair Lewis; André Malraux; Gertrude Stein and Thornton Wilder. Among the poets there are files for W. H. Auden; Allen Ginsberg; Robinson Jeffers; Robert Lowell; and Stephen Spender. In the area of theater there are files for Maxwell Anderson; Moss Hart; Lillian Hellman; Eugene O'Neill; and Tennessee Williams. Random House transacted business with many fine presses and noted typographers and the archives contain files for Nonesuch Press, Grabhorn Press and Golden Cockerel Press, as wll as for Bruce Rogers, Valenti Angelo, and Edwin, Jane, and Robert Grabhorn.

The collection includes the original manuscript of "Surrender on Demand", Mr. Fry's account of his wartime experiences, which was later rewritten for young readers as "Assignment Rescue" (New York, Four Winds Press, 1968). Among the correspondents represented in the collection are Marc Chagall, Jacques Lipchitz, Roger Baldwin, Norman Thomas, J. Edgar Hoover, and Herman Wouk. In addition to the material relating to the Emergency Relief Committee (later known as the International Rescue Committee), the collection includes correspondence and papers concerning Fry's work as a writer on foreign affairs as well as copies of his books.