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Correspondence, manuscripts, notes, notebooks, documents, photographs, course-related materials, and printed materials. The manuscripts include typescripts of Sykes' published and unpublished novels, monographs, plays, short stories, and articles. Among these are The Perennial Avant Garde, The Cool Millennium, and The Hidden Remnant. Sykes' notes and notebooks span the period from the early 1930s to 1980, and include preliminary ideas and sketches for his books, as well as autobiographical material. A small number of documents concern Sykes' wartime work in the U.S. Government Office of War Information. Course-related material including writings and correspondence of students taught by Sykes between 1962 and 1975 at the New School and as an adjunct professor at Columbia University. Printed materials consist of numerous reviews of Sykes' books, in addition to offprints and articles by Sykes. Included as well are printed materials about or connected with Sykes, offprints of articles inscribed to him, and many volumes from his library. The substantial correspondence series includes personal letters and correspondence with agents and publishers relating to his books. Correspondents include Harold Clurman, Aaron Copland, Lawrence Durrell, Georgia O'Keeffe, and Francis Steegmuller, as well as a number of Sykes' students. There is extensive correspondence between Sykes and the artist John Hartell from 1927 to 1983.

Correspondence, manuscripts, dispatches, documents, clippings and other printed materials concerning his career as an editor and correspondent for the New York Herald Tribune in Moscow, Berlin and New York, as a staff member of the Institute of Pacific Relations from 1932 to 1934, as deputy director in the Office of War Information overseas branch, 1941-44, as an owner and editor of the New York Star, 1948-49, as an instructor in communications at Sarah Lawrence College, 1950-1951, as a book editor at Simon and Schuster, Publishers, 1951-1970, and as an author and translator.

The collection consists of the editorial and production archives of Vanguard Press: correspondence, manuscripts, contracts, memoranda, galley proofs, photographs, clippings, and printed materials. The correspondence and editorial files contain a wealth of detailed information about individual authors and the growth and development of the Press. Among the cataloged correspondents are: Nelson Algren, Saul Bellow, Stephen Vincent Benét, William Rose Benét; Phyllis Bottome; Pierre Boulle; Jocelyn Brooke; Cyril Connolly; A.J. Cronin; Nigel Dennis; John Dewey; Max Eastman; James T. Farrell; Vardis Fisher; Richard Garnett; Theodor Seuss Geisel; Louis Golding; Paul Goodman; Horace Gregory; Geoffrey Grigson; Lillian Hellman; William Heyen; Harold L. Ickes; Christopher Isherwood; Alfred Kazin; Philip Lamantia; Sinclair Lewis; Emanuel Litvinoff; Dwight Macdonald; Archibald MacLeish; Marshall McLuhan; Thomas Mann; Edgar Lee Masters; H. L. Mencken; William Meredith; Joyce Carol Oates; Katherine Anne Porter; Barbara Pym; William Sansom; William Saroyan; Ramon J. Sender; Upton Sinclair; Rex Stout; Edith Sitwell; Paul Theroux; Lionel Trilling; Harry S. Trumam; Louis Untermeyer; Eudora Welty; Richard Wilbur; and Thornton Wilder. There are some manuscripts by Bellow; Bottome; Boulle; Farrell; Grigson; Litvinoff; MacDonald; Oates; John Cowper Powys; Arthur Schlesinger, Jr.; Patrick Tanner; William Targ; Theroux; and Sitwell.